As it is usually considered to be more of a priviledge to sit closer to the Bridal table it is important to consider the Bride and Groom's closest family and friends when seating these tables.  

At the same time, if your relatives are touchy about music levels from the DJ or Band, place them as far from the speakers as possible.  This way the music levels can be at a level that everyone can enjoy.

Some couples feel it is a good idea to break up groups of friends and sit them with new people so everyone gets to meet someone new.  While others are more comfortable placing groups of friends together.  

Ultimately its your choice, and a compromise seating plan which puts groups of several friends together on a table may avoid guests feeling left out.  After all, It is human nature to want to sit with your friends.

Basic rules of thumb for seating

• Sit couples together
• Sit friends with friends
• Position tables so that if friends are separated they are only a table away
• Sit closest friends and relatives closer to the Bridal Table.
• Position divorced couples and guests who don't get along as far away as possible from each other - but with their respective friends. (These guests always make seating plans more challenging)
• There is no need for male next to female - its up to you.
• Sit guests who know few people with your more socially adept guests so they can join in